We discussed Nucleotide Sequence Databases
Distinguishing structure of eukaryotic and prokaryotic proteins
Eukaryotic DNA in nucleus, nuclear DNA
mRNA-photocopy of DNA that is carried to Ribosomes
alternative splicing-introns "comment" out segments of exons (information) to generate many types of proteins
Eukaryotes (1 gene/1Kb) are very complex compared to Prokaryotes (1 gene/100Kb)
GenBank – housed by national Center of Biotechnoloies
memory of biological science; many biologists send genes they find to keep the database up-to-date
Reading a Prokaryotic GenBank entry (p75)
ACESSION is the accession number
LOCUS contains information on gene size
ORGANISM defines the organism containing the gene
REFERNECE indicates who produces the gene
FEATURES
Reading a Eukaryotic GenBank entry
Gene-centric databases: pieces genes together to work with; uses GenBank data; Entrez Gene genome
ENSEMBLE visualization of human chromosomes – can click and zoom on various parts of a chromosome
TIGR Institute
DoE Joint Genome Institute
University of California – good alternative to ENSEMBL; is a mirror site
We had many good discussions. The meeting was very productive.
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